ENTtoday
  • Home
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Multimedia
    • Video
    • Audio
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
    • eNewsletters
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

Laser Treatment Resolves Glottic Cancer in a Pilot Study

by Ed Susman • June 1, 2008

  • Tweet
  • Email
Print-Friendly Version

ORLANDO, FL-Laser involution of early stage glottic cancer-with complete treatment of the malignancy weeks after the first session-appears to offer long-term control of the disease while preserving excellent voice function, researchers reported at the 88th annual meeting of the American Broncho-Esophagological Association (ABEA).

You might also like:

  • Transoral Laser Resection for Early Glottic Cancer
  • Laser, Radiotherapy Appear Similar in Oncologic Outcomes for Glottic Cancer
  • Pulsed-Dye Laser May Be Useful for Vocal Fold Scarring
  • Laser Treatment for Laryngeal Cancer: Good Results-and Complex Questions
Explore this issue:
June 2008
Amy Chen, MD, MPH

Amy Chen, MD, MPH

In a preliminary report that described treatment of 23 patients, Steven M. Zeitels, MD, Eugene B. Casey Professor of Laryngeal Surgery at Harvard Medical School in Boston, suggested that treatment with pulsed angiolytic lasers might offer a better solution for laryngeal cancer than ionizing radiation.

This is somewhat unconventional, Dr. Zeitels said during the ABEA session, which was conducted as part of the annual Combined Otolaryngology Spring Meeting. I’ll ask you to keep an open mind.

He said the use of pulsed angiolytic lasers has previously been demonstrated to be effective for managing vocal fold dysplasia.

Based on this experience, we evaluated treating early glottic cancers by selectively targeting the intralesional microcirculation, Dr. Zeitels said. Initially we used the yellow-light 585-nm pulsed-dye laser, but ultimately abandoned it. For the past three years, the 532-nm pulsed-KTP [potassium titanyl phosphate] laser was used exclusively because it provides substantially enhanced precision, as well as being less expensive. This approach was derived from the work of the late Judah Folkman’s concepts of neoplastic growth resulting from tumor angiogenesis.

Staged microlaryngeal treatment was adopted because it facilitated optimal functional results and was considered safe because early glottic cancer rarely metastasizes. Furthermore, intercurrent disease for around three months is typical when treating these tumors with radiotherapy, he said.

Dr. Zeitels also noted that the initial angiolytic laser endoscopic management of glottic cancer with lasers still preserves other treatment options including other forms of surgery and radiation.

Study Results

Among the 23 patients, 13 had cancer in both vocal folds; 13 presented with T1 disease, nine had T2 disease, and one had T4 disease. Dr. Zeitels said that among these patients one recurrence was observed, but retreatment with the laser involuted the tumor and that patient has now been subsequently free of disease for more than two years.

All the patients have no evidence of disease, and 13 of them had treatment more than two years ago. The mean follow-up was 28 months. The longest a patient has cancer-free subsequent to the laser treatment has been 5.5 years, Dr. Zeitels said in his oral presentation.

Dr. Zeitels used the 585-nm pulsed-dye laser in the initial eight patients and the 532-nm pulsed-KTP laser in the last 15 patients to eradicate the vocal fold tumors. Both lasers are capable of involuting vocal fold cancer; however, we observed the pulsed-KTP laser to be more effective, he said. Incremental endolarygneal treatment of early glottic cancer is safe and allows for substantially better functional outcome.

Pages: 1 2 3 Single Page

Filed Under: Departments, Laryngology, Medical Education, Practice Focus, Tech Talk Tagged With: cancer, carcinoma, COSM, laser, outcomes, research, surgery, technology, testing, treatmentIssue: June 2008

You might also like:

  • Transoral Laser Resection for Early Glottic Cancer
  • Laser, Radiotherapy Appear Similar in Oncologic Outcomes for Glottic Cancer
  • Pulsed-Dye Laser May Be Useful for Vocal Fold Scarring
  • Laser Treatment for Laryngeal Cancer: Good Results-and Complex Questions

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • How Physicians Can Build a Network to Boost Their Career
  • How To Survive the First Year of Medical Residency
  • ACGME Revises Cap on Resident Work Hours
  • Ethical Implications of Burnout in Otolaryngology Residents
  • How Physicians Can Plan for Maternity Leave
  • Popular this Week
  • Most Popular
  • Most Recent
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Vertigo in the Elderly: What Does It Mean?
    • Women in Otolaryngology: Do we belong here?
    • Otolaryngology’s #MeToo: Gender Bias and Sexual Harassment in Medicine
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • Vertigo in the Elderly: What Does It Mean?
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Post-Operative Pain in Children Undergoing Tonsillectomy
    • Otolaryngology’s #MeToo: Gender Bias and Sexual Harassment in Medicine
    • Women in Otolaryngology: Do we belong here?
    • Letter from the Editor: We All Need to Take #MeToo Personally
    • What Otolaryngologists Should Consider When Prescribing Opioids
    • What Additional Treatment Is Indicated for Oral Cavity Cancer with Isolated Perineural Invasion?

Polls

Have you experienced or witnessed sexual discrimination or harassment in your workplace?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy

Visit: The Triological Society • The Laryngoscope • Triological Meeting Posters

Wiley
© 2018 The Triological Society. All Rights Reserved.
ISSN 1559-4939

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.