Induction Chemotherapy in Oropharynx Cancers Produces Good Long-Term Outcomes

Neoadjuvant, systemic therapy and surgical resection followed by risk-adapted adjuvant therapy resulted in high response rates and excellent long-term outcomes, allowing a high number of patients to avoid radiation therapy.

Background: Treatment of locally advanced oropharynx cancer has evolved substantially, with chemoradiotherapy offering an alternative to large, morbid surgical resections. Induction chemotherapy has been proposed for both HPV-positive patients who have a good prognosis, to de-intensify definitive radiation therapy for patients with an excellent response, and for those with a poorer prognosis, as an additive therapy to standard care.

Study design: Retrospective case-control study of 40 patients accrued between October 3, 2012, and August 23, 2016.

Setting: Department of Hematology and Oncology, Lineberger Comprehensive Cancer Center at the University of North Carolina, Chapel Hill.

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