MFH has variable pathophysiology and many subtypes. Tumors contain both fibroblast-like and histiocyte-like cells in varying proportions, giving rise to five major subtypes: storiform/pleomorphic (most common); myxoid; giant cell; inflammatory (usually not seen in the head and neck); and angiomatoid-although the last may be a distinct, more indolent, disease. Dr. Sturgis said that most sarcoma pathologists think that MFH is poorly differentiated.
However, said David W. Clark, MD, of the Department of Otolaryngology-Head and Neck Surgery at University of Texas Health Science Center at Houston, Some people argue that the histiologic subtypes are no longer pertinent and that MFH represents a group of unclassifiable sarcomas, and hence is synonymous with pleomorphic undifferentiated sarcoma.
Myogenically differentiated tumors that suggest muscle origin can behave more aggressively, so a thorough pathology investigation is necessary to ensure accurate classification.| ← Previous | | | Next → | Single Page