Are Neuromodulating Medications Effective for Treatment of Chronic Neurogenic Cough?

Background

Chronic cough is vexing for patients and is an extremely common chief complaint in ambulatory settings. A cough persisting longer than eight weeks is considered chronic, and many patients seek evaluation by an otolaryngologist. After considering a broad differential, including reflux, chronic rhinitis/sinusitis, primary pulmonary diagnosis, and medication side effects, the diagnosis of chronic neurogenic cough can be considered.

Both peripheral neuropathy and central sensitization/potentiation of the cough reflex have been implicated in the pathophysiology of chronic neurogenic cough. Thus pharmacologic neuromodulators have been used in patients with chronic neurogenic cough to reduce cough severity and to improve cough-related quality of life.

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