Can postoperative steroid requirements for controlling mucosal inflammation provide insight into predicting which patients require more aggressive medical therapy to prevent disease relapse after sinus surgery for chronic rhinosinusitis (CRS)?
Bottom line: Tissue eosinophil aggregates appear to be the largest driving factor for increased prednisone requirements after sinus surgery to control mucosal disease than the mere presence of eosinophils. This finding may identify patients at high risk for sinus surgery failure and guide more proactive postoperative management.
Explore this issue:April 2019
Background: CRS without nasal polyps (CRSsNP) is often associated with increased fibrosis, goblet cell hyperplasia, and neutrophilia, while CRS with nasal polyps (CRSwNP) demonstrates predominantly edematous stroma with albumin deposition, pseudocyst formation, and eosinophilia. To date, limited research has investigated the postoperative steroid requirements of specific CRS endotypes beyond these binary models.
Study design: Retrospective chart review of 101 patients (42 CRSwNP, 59 CRSsNP) who underwent functional endoscopic sinus surgery (FESS) for refractory CRS.| | | Next → | Single Page