By Mihai A. Bentan, BA, Graham Pingree, BA, Lawrance Lee, MD, Thomas Fitzpatrick, MD, and Theodore Schuman, MD (doi.org/10.1002/lary.31774)
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December 2025The authors compare the efficacy of th2-targeted biologic medications (dupilumab, omalizumab, and mepolizumab) on absolute risk reduction of functional endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) and allergic fungal rhinosinusitis.
Natural History of Untreated Idiopathic Sudden Sensorineural Hearing Loss
By Yu-Lan Mary Ying, MD, Christopher C. Tseng, MD, Jennifer Shin, MD, SM, and Steven Rauch, MD (doi.org/10.1002/ lary.31474)
Although corticosteroids and other treatments for idiopathic sudden sensorineural hearing loss have been described, understanding its prognosis without intervention provides valuable information for patient management. The objective of this study is to provide a comprehensive, quantitative statistical analysis of the natural history of untreated idiopathic sudden sensorineural hearing loss.
Costs of Severe to Profound Hearing Loss & Cost Savings of Cochlear Implants
By Ivette Cejas, PhD, David H. Barker, PhD, Esteban Petruzzello, PhD, Christina M. Sarangoulis, BA, and Alexandra L. Quittner, PhD (doi.org/10.1002/lary.31497)
This study aims to estimate the costs of severe to profound hearing loss, including costs and cost savings associated with cochlear implantation.
Does Total Turbinectomy Always Lead to Empty Nose Syndrome? A Computational Virtual Surgery Study
By Ahmad Odeh, BS, Raymond Wen, BS, Zhenxing Wu, Aspen R. Schneller, BS, Zachary T. Root, BS, Bradley Hittle, Gregory J. Wiet, MD, Bradley A Otto, Kathleen M Kelly, and Kai Zhao ( doi. org/10.1002/lary.31757)
Computational fluid dynamics modeling has previously indicated that distorted nasal airflow patterns may contribute to empty nose syndrome (ENS); however, no data show that aggressive turbinate surgery always leads to ENS. We aim to use virtual surgery planning to investigate how a total inferior turbinectomy affects airflow parameters compared with ENS patients.
Does ChatGPT Answer Otolaryngology Questions Accurately?
By Matthew Maksimoski, MD, Anisha Rhea Noble, MD, and David F. Smith, MD, PhD (doi.org/10.1002/lary.31410)
The authors investigate the accuracy of ChatGPT in the manner of medical questions related to otolaryngology.
By Kourosh Eftekharian, MD, MPH, Elnaz Najafi, MD, Maryam Amizadeh, MD, Noosheen Mokari, MS, Mohammad Faramarzi, MD, Yalda Izadparast, MD, Yalda Jabbari Moghadam, MD, and Ali Eftekharian, MD (doi.org/10.1002/lio2.70054)
The authors compare the hearing outcomes of patients with idiopathic sudden sensorineural hearing loss after intratympanic injection of methylprednisolone and dexamethasone.

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