ENTtoday is the official news magazine of the Triological Society, and its two sister publications—The Laryngoscope and Laryngoscope Investigative Otolaryngology—are the official peer-reviewed journals. Here’s a look at the top 10 most-read articles from each journal from 2024.
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December 2025
By Jinhui Chen, MD, Ping Zhou, MM, Jingjing Zuo, MD, Wei Ming, MD, Ting Huang, MM, and Zezhang Tao, MD (doi.org/10.1002/lary.31378)
We aim to increase surgeons’ awareness of the various types of preauricular sinuses (PAS) by summarizing our experience in diagnosing and treating these different types.
Washing Illness Away: A Systematic Review of the Impact of Nasal Irrigation and Spray on COVID‐19
By Karan Gandhi, MD, Freeman Paczkowski, BHSc, and Leigh Sowerby, MD, MHM, FRCSC (doi.org/10.1002/lary.31761)
Nasal irrigation is a common treatment for sinonasal disorders; however, it is unknown if it can reduce SARS-CoV-2 nasopharyngeal viral load. This systematic review investigated the efficacy of nasal irrigation with saline, povidone iodine, and intranasal corticosteroids at reducing SARS-CoV-2 NVL and transmissibility.
Effect of Hormone Replacement Therapy on Chronic Rhinosinusitis Management
By Kevin Herrera, BS, Miti Parikh, BA, Sahiti Vemula, BS, and Kevin Hur, MD (doi.org/10.1002/lary.31433)
The study investigates whether hormone replacement therapy impacts healthcare resource utilization in the management of chronic rhinosinusitis in older women.
Real‐World Adverse Events After Type 2 Biologic Use in Chronic Rhinosinusitis with Nasal Polyps
By Marisa Dorling, BSc, Juan C. Hernaiz-Leonardo, MD, Athenea Pascual, PhD, Arif Janjua, MD, FRCSC, Andrew Thamboo, MD, FRCSC, and Amin Javer, MD, FRCSC (doi.org/10.1002/lary.31305)
This study investigates the frequency and nature of adverse events related to type 2 biologic use in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), including dupilumab and mepolizumab.
By Peter L. Friedland, MD, and Simon Tucker, PhD (doi.org/10.1002/lary.31430)
A Phase II trial was conducted to determine if nasal disinfection with a commercial Good Manufacturing Practice-manufactured 0.5% povidone-iodine nasal spray (Nasodine®) may be a useful adjunct in the management of COVID-19 by reducing viral shedding and preventing transmission of SARS-CoV-2. The aim was to confirm the results from a human single-dose pilot study by assessing repeated and frequent doses on nasal shedding of SARS-CoV-2 from adult subjects with confirmed COVID-19.
Impact of Biologics on Surgery in Chronic Rhinosinusitis with Polyps and Allergic Fungal Sinusitis
By Mihai A. Bentan, BA, Graham Pingree, BA, Lawrance Lee, MD, Thomas Fitzpatrick, MD, and Theodore Schuman, MD (doi.org/10.1002/lary.31774)
The authors compare the efficacy of th2-targeted biologic medications (dupilumab, omalizumab, and mepolizumab) on absolute risk reduction of functional endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) and allergic fungal rhinosinusitis.
Natural History of Untreated Idiopathic Sudden Sensorineural Hearing Loss
By Yu-Lan Mary Ying, MD, Christopher C. Tseng, MD, Jennifer Shin, MD, SM, and Steven Rauch, MD (doi.org/10.1002/ lary.31474)
Although corticosteroids and other treatments for idiopathic sudden sensorineural hearing loss have been described, understanding its prognosis without intervention provides valuable information for patient management. The objective of this study is to provide a comprehensive, quantitative statistical analysis of the natural history of untreated idiopathic sudden sensorineural hearing loss.
Costs of Severe to Profound Hearing Loss & Cost Savings of Cochlear Implants
By Ivette Cejas, PhD, David H. Barker, PhD, Esteban Petruzzello, PhD, Christina M. Sarangoulis, BA, and Alexandra L. Quittner, PhD (doi.org/10.1002/lary.31497)
This study aims to estimate the costs of severe to profound hearing loss, including costs and cost savings associated with cochlear implantation.
Does Total Turbinectomy Always Lead to Empty Nose Syndrome? A Computational Virtual Surgery Study
By Ahmad Odeh, BS, Raymond Wen, BS, Zhenxing Wu, Aspen R. Schneller, BS, Zachary T. Root, BS, Bradley Hittle, Gregory J. Wiet, MD, Bradley A Otto, Kathleen M Kelly, and Kai Zhao ( doi. org/10.1002/lary.31757)
Computational fluid dynamics modeling has previously indicated that distorted nasal airflow patterns may contribute to empty nose syndrome (ENS); however, no data show that aggressive turbinate surgery always leads to ENS. We aim to use virtual surgery planning to investigate how a total inferior turbinectomy affects airflow parameters compared with ENS patients.
Does ChatGPT Answer Otolaryngology Questions Accurately?
By Matthew Maksimoski, MD, Anisha Rhea Noble, MD, and David F. Smith, MD, PhD (doi.org/10.1002/lary.31410)
The authors investigate the accuracy of ChatGPT in the manner of medical questions related to otolaryngology.
By Kourosh Eftekharian, MD, MPH, Elnaz Najafi, MD, Maryam Amizadeh, MD, Noosheen Mokari, MS, Mohammad Faramarzi, MD, Yalda Izadparast, MD, Yalda Jabbari Moghadam, MD, and Ali Eftekharian, MD (doi.org/10.1002/lio2.70054)
The authors compare the hearing outcomes of patients with idiopathic sudden sensorineural hearing loss after intratympanic injection of methylprednisolone and dexamethasone.
By Johannes Bier, MD, Alexandra Klingner, DMD, Rupert Stadlhofer, MD, Christian S. Betz, MD, and Arne Böttcher, MD (doi.org/10.1002/lio2.1248)
Nasal septum perforation is a common condition affecting around 1.2% of the general population and is still considered challenging to treat. Therapeutic strategies range from conservative local treatments and septal button closures to over 40 different surgical approaches. This study aimed to present a novel secure approach.
By Ahmad R. Sedaghat, MD, PhD, Manuel Bernal-Sprekelsen, MD, PhD, Wytske J. Fokkens, MD, PhD, Timothy L. Smith, MD, MPH, Michael G. Stewart, MD, MPH, and Romaine F. Johnson, MD, MPH (doi.org/10.1002/lio2.1266)
The peer review process is critical to maintaining quality, reliability, novelty, and innovation in scientific literature. The teaching of scientific peer review is rarely a component of formal scientific or clinical training, however, and even the most experienced peer reviewers express interest in continuing education. The objective of this review article is to summarize the collective perspectives of experienced journal editors about how to be a good reviewer in a step-by-step guide that can serve as a resource for the performance of peer review of a scientific manuscript.
Inhaled Fosamprenavir for Laryngopharyngeal Reflux: Toxicology and Fluid Dynamics Modeling
By Alexandra Lesnick, BS, Tina L. Samuels, MS, Donna Seabloom, BS, Beverly Wuertz, BS, Abhilash Ojha, MS, Davis Seelig, DVM, PhD, DACVP, Frank Ondrey, MD, Timothy S. Wiedmann, PhD, Chris Hogan, PhD, Emma Torii, BVSc, MANZCVS, DACVP, Hui Ouyang, PhD, Ke Yan, PhD, Guilherme J. M. Garcia, PhD, Jonathan M. Bock, MD, FACS, and Nikki Johnston, PhD (doi. org/10.1002/lio2.1219)
Approximately 25% of Americans suffer from laryngopharyngeal reflux (LPR), a disease for which no effective medical therapy exists. Pepsin is a predominant source of damage during LPR and a key therapeutic target. Fosamprenavir (FOS) inhibits pepsin and prevents damage in an LPR mouse model. Inhaled FOS protects at a lower dose than oral; however, the safety of inhaled FOS is unknown, and there are no inhalers for laryngopharyngeal delivery. A pre-Good Lab Practice (GLP) study of inhaled FOS was performed to assess safety, and computational fluid dynamics (CFD) modeling was used to predict the optimal particle size for a laryngopharyngeal dry powder inhaler (DPI).
The Cavernous Sinus: An Anatomic Study with Clinical Implications
By Myles L. Pensak, MD (doi. org/10.1002/lio2.1226)
The management of lesions involving the cavernous sinus remains a formidable challenge. To optimize care for patients with tumors extending into this skull base region, a detailed understanding of the surrounding osteology, as well as neural and vascular relationships, is requisite. This thesis examines the gross anatomy of the region and highlights important surgical implications drawn from these, as well as previously published studies.
By Saad Alsaleh, MBBS, FRCSC, Nehal Kamal, BSc Pharma, Claire Hopkins, DM, Hussain Al Rand, MD, Facharzt, Osama A. Marglani, MD, FRCSC, Abdulmohsen Alterki, FRCSC, Omar Abu Suliman, MBBS, FACS, Talal Alandejani, MD, FRCSC, Reda Kamel, MD, Rashid Al Abri, MD, FRCS, Naif H. Alotaibi, MD, MSc, Ahmad Al Amadi, MBChB, FRCS, Abdullah Bahakim, MD, D.E.S, Joseph K. Han, MD, FARS, FAAAAI, Amin Javer, MD, FRCSC, FARS, Ahmad R. Sedaghat, MD, PhD, and Philippe Gevaert, MD, PhD (doi.org/10.1002/lio2.1277)
Chronic rhinosinusitis is a heterogeneous disorder with a wide range of validated subjective and objective assessment tools to assess disease severity. A comprehensive and easy-to-use tool that integrates these measures for determining disease severity and response to treatment, however, is still obscure. The objective of this study was to develop a standardized assessment tool that facilitates diagnosis, uniform patient monitoring, and comparison of treatment outcomes between different centers, both in routine clinical practice and in research.
Modified Technique Improves Efficacy for In‐Office Posterior Nasal Nerve Ablation
By Daniel Gorelik, MD, MPH, Aatin K. Dhanda, BA, Alexander Choi, MD, Masayoshi Takashima, MD, Najm S. Khan, MBS, Nicholas R. Rowan, MD, Aria Jafari, MD, Tariq Syed, MS, and Omar G. Ahmed, MD (doi.org/10.1002/lio2.1238)
Posterior nasal nerve ablation is a minimally invasive treatment option for patients with chronic rhinitis. Recent evidence shows that parasympathetic innervation of the nasal cavity is more extensive, and there are many fibers posterior to the lateral attachment of the middle turbinate. We describe a modified ablative technique that targets the extensive innervation of the posterior nasal nerves.
Proposal for Standardized Ultrasound Analysis of the Salivary Glands: Part 1 Submandibular Gland
By Henry T. Hoffman, MD, Michael Koch, MD, Robert Lee Witt, MD, William R. Ryan, MD, Johannes Zenk, MD, Philippe Katz, MD, Rahmatullah Rahmati, MD, Christopher Rassekh, MD, Francisco Donato, MD, Timothy M. McCulloch, MD, Arjun S. Joshi, MD, Jolie Lien Chang, MD, M. Boyd Gillespie, MD, Priscilla F. A. Pichardo, DO, Lisa Ann Orloff, MD, Antonio Marcelino, MD, Piper Wenzel, BS, David Cohen, MD, Christopher E. Fundakowski, MD, David M. Cognetti, MD, Rohan R. Walvekar, MD, Antonio Bertelli, MD, Harry Quon, MD, Carryn Anderson, MD, Bruno Policeni, MD, and Gordy Siegel, MD (doi.org/10.1002/ lio2.1224)
The Salivary Gland Committee of the American Academy of Otolaryngology– Head and Neck Surgery seeks to standardize terminology and technique for ultrasonography used in the evaluation and treatment of salivary gland disorders.
Outpatient Management of Pediatric Epistaxis: A Cost Analysis and Clinical Model
By Joshua A. Lee, MD, Christopher Puchi, MD, Kathleen R. Billings, MD, Jennifer M. Lavin, MD, MS, Inbal Hazkani, MD, Carole Glennon, RN, MSN, CPN, Dana M. Thompson, MD, MS, MBA, and John Maddalozzo, MD (doi.org/10.1002/ lio2.1310)
Pediatric epistaxis is a common, often non-operative condition encountered by otolaryngologists. The present study seeks to describe our outcomes of epistaxis management, estimate the associated healthcare burden, and propose a clinical model to optimize care coordination with primary care and advanced practice providers.
Cerumen Impaction: Prevalence and Associated Factors in the United States Population
By McKenzie M. Tolan, MD, Janet S. Choi, MD, MPH, Maria T. Tibesar, BS, and Meredith E. Adams, MD, MS (doi. org/10.1002/lio2.1228)
The authors examine the prevalence of cerumen impaction in a nationally representative sample of the U.S. population and the association of cerumen impaction with sociodemographic factors, hearing loss, and tinnitus.
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