Comment: Several studies over the past 10 years have suggested that daily aspirin use can prevent tumor growth in some types of cancer, most notably colorectal. These studies likely prompted several groups to investigate the use of aspirin in controlling the growth of vestibular schwannomas. Between 2014 and 2017 at least four studies addressed this issue, and at least one of these shows a salutary effect. This form of therapy is very appealing due to its relatively low risk, common use, and ease of availability. The study by MacKeith and colleagues uses a case-control design, and, in a total of 437 patients did not show the ability to stem the growth of these neoplasms. —Samuel H. Selesnick, MD
Is aspirin intake is associated with reduced growth of vestibular schwannomas (VS)?