ENTtoday
  • Home
  • COVID-19
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

Cleft Palates Predict Higher Risk for Surgically Treated Cholesteatoma

by Amy Hamaker • May 6, 2015

  • Tweet
  • Email
Print-Friendly Version

What risk of surgically treated middle ear cholesteatoma do individuals with a nonsyndromic orofacial cleft and their siblings face compared with the general population?

Background: Individuals with an orofacial cleft have a predisposition to middle ear disease. Impaired Eustachian tube function with negative middle ear pressure may cause a retraction pocket, generally considered a main component in cholesteatoma development. In unaffected relatives of cleft lip (CL) cases, ultrasonography has demonstrated orbicularis oris muscle defects that have been suggested as an expanded CL phenotype. Due to the rarity of orofacial clefts and cholesteatomas, epidemiologic studies require large study populations and long observation periods to analyze possible correlations.

You Might Also Like

  • Can Radiologic Imaging Replace Second-Look Procedures for Cholesteatoma?
  • Intraoperative Endoscope Use Reduces Cholesteatoma Recurrence, Cost
  • High-Resolution CT and Diffusion-Weighted MRI Combo Improves Pediatric Cholesteatoma Detection
  • No Evidence for Mucosal Migration Theory of Cholesteatoma Formation
Explore This Issue
May 2015

Study design: Historical cohort study of 8,593 nonsyndromic individuals from Jan. 1, 1977, until time of surgically treated cholesteatoma—and censored at emigration, death, or end of follow-up (Dec. 31, 2010)—plus a total of 6,989 siblings.

Setting: Three national registers for the Danish 1936–2009 birth cohorts.

Synopsis: Kaplan-Meier plots showed a considerably increased risk of first surgically treated middle ear cholesteatoma (STMEC1) in the cleft lip and palate (CLP) and cleft palate (CP) groups, but not in the CL group. Cox regression analysis demonstrated a 20-fold increased risk of STMEC1 in the CP group and a 14-fold increased risk in the CLP group, but no increased risk in the CL group. There was a decreasing risk of STMEC1 with increasing birth decade that was only significant for the earliest birth decades. Kaplan-Meier plots showed an increased STMEC1 risk in siblings of CP cases. Cox regression analysis demonstrated a 2.1-fold increased risk of STMEC1 in siblings of CP cases, but no increased risk in siblings of CL or CLP cases. There was strong evidence of an almost 20-fold increased risk of STMEC1 for the CP group but not for the CL group. Limitations included a risk of register study misclassification, the possible incorrect inclusion of patients operated on before 1977 as new STMEC1 cases, a limitation of the National Patient Register’s data content to outpatients from 1995 onward, and possible discrepancies in the criteria used for making a cholesteatoma diagnosis between surgeons.

Bottom line: A 20-fold increase in cholesteatoma risk was found in CP individuals, while CL did not pose this risk; furthermore, there was an increased risk of cholesteatoma in unaffected siblings of CP individuals.

Citation: Djurhuus BD, Skytthe A, Faber CE, Christensen K. Cholesteatoma risk in 8,593 orofacial cleft cases and 6,989 siblings: a nationwide study. Laryngoscope. 2015;125:1225-1229.

Pages: 1 2 | Single Page

Filed Under: Otology/Neurotology Tagged With: Cholesteatoma, cleft palateIssue: May 2015

You Might Also Like:

  • Can Radiologic Imaging Replace Second-Look Procedures for Cholesteatoma?
  • Intraoperative Endoscope Use Reduces Cholesteatoma Recurrence, Cost
  • High-Resolution CT and Diffusion-Weighted MRI Combo Improves Pediatric Cholesteatoma Detection
  • No Evidence for Mucosal Migration Theory of Cholesteatoma Formation

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Vertigo in the Elderly: What Does It Mean?
    • Experts Delve into Treatment Options for Laryngopharyngeal Reflux
    • Non-Acidic Reflux Explains Lack of Response to H2 Blockers and PPIs
    • How 3D Printing Is Transforming the Pediatric Otolaryngology Field
    • Vertigo in the Elderly: What Does It Mean?
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Why Virtual Grand Rounds May Be Here to Stay
    • Otolaryngologist Leverages His Love of Pinball into Second Business
    • These New Imaging Advances May Help to Protect Parathyroids
    • Is the Training and Cost of a Fellowship Worth It? Here’s What Otolaryngologists Say
    • Which Otologic Procedures Poses the Greatest Risk of Aerosol Generation?

Polls

Have you used 3D-printed materials in your otolaryngology practice?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2021 The Triological Society. All Rights Reserved.
ISSN 1559-4939

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.