Facial Cellulitis in Older Man Presents Variability in Diagnosis

Histopathology examination revealed eosinophilic cellulitis. The fine needle aspiration was significant for scattered leukocytes and stroma. The patient was started on oral doxycycline and prednisone, 40 mg a day, with a daily topical Biafine foam dressing. Significant clinical response was seen at two-week follow-up, with near complete resolution at one month. He was tapered off the prednisone at that time. At six months, there were no clinical signs present.

Discussion

Diagnosis of eosinophilic cellulitis is obtained by a combination of clinical presentation andhistopathologic findings. While skin biopsies may show eosinophilic infiltration, phagocytic histiocytes, and often flame figures, diagnosis can be delayed by nondiagnostic samples. The experience of the pathologist and the quality of the sample are crucial. Flame figures are frequently present in this disease (50% to 96%) and often considered pathognomonic.^1,2 Eosinophilia is not always present in the peripheral blood smears and occurred in only 50% of patients in one review.¹ Leukocytosis is also particularly insensitive and may be present in only 40% of cases.²

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Figure 2. (A) Punch biopsy of the left neck lesion with thickened stratum corneum and leukocytosis. (B) High powered field showing extensive eosinophilic infiltrate.

While a presentation similar to bacterial cellulitis is common, a significant degree of clinical polymorphism may further complicate diagnostic efforts. Recent studies have reported cutaneous variants with nodular, bullous, papulonodular, plaque-like, annular granuloma-like, and urticaria-like lesions. Based on this heterogeneity, one author suggested dividing eosinophilic cellulitis into distinct subtypes to better categorize the disease.¹ This case of ulcerated, crusting, and fungating lesions with subdermal plaques further supports its variability and may showcase a novel presentation.^1,2

Treatment involves systemic steroids and may include histamine blockers and topical anti-inflammatories, but the recurrence rate ranges from 56% to 100%.^1-4 The natural course of the disease is also variable and may include a relapsing/remitting cycle, although some patients do experience remission even with appropriate treatment. The clinical progression depicted in this case report highlights how this disease process can mimic head and neck malignancy.

References

1. Caputo R, Marzano AV, Vezzoli P, Lunardon L. Wells syndrome in adults and children: a report of 19 cases. Arch Dermatol. 2006;142:1157-1161.
2. Sinno H, Lacroix JP, Lee J, et al. Diagnosis and management of eosinophilic cellulitis (Wells’ syndrome): a case series and literature review. Can J Plast Surg. 2012;20:91-97.
3. Gandhi RK, Coloe J, Peters S, Zirwas M, Darabi K. Wells Syndrome (eosinophilic cellulitis): a clinical imitator of bacterial cellulitis. J Clin Aesthet Dermatol. 2011;4:55-57.
4. Weiss G, Shemer A, Confino Y, Kaplan B, Trau H. Wells’ syndrome: report of a case and review of the literature. Int J Dermatol. 2001;40:148-152.