How feasible is a 22-day proton pump inhibitor (PPI) weaning protocol in a cohort of patients following successful empiric treatment for suspected laryngopharyngeal reflux disease (LPRD)?
Approximately 66% of patients who were on PPIs for LPRD were successfully weaned. High BMI was significantly predictive of failure to wean.
Explore this issue:January 2018
Background: Many physicians prefer an empiric trial of PPI therapy as the first step in patients with symptoms suggestive of LPRD. However, PPIs are not without side effects, and the role of long-term versus short-term PPI therapy for LPRD is not known. A gradual wean is favored over abrupt discontinuation due to rebound gastric acid hypersecretion upon cessation of treatment.
Study design: Retrospective chart review of 35 patients.