While recent reports show that phosphodiesterase-5 (PDE-5) inhibitors can cause sudden sensorineural hearing loss (SSHL), what is the global experience of this phenomenon?
Background: SSHL has been reported after the ingestion of a PDE-5 inhibitor such as Viagra. SSHL has been defined as hearing loss of at least 30 dB in three or more continuous frequencies occurring within 72 hours of symptoms onset.
Explore this issue:May 2011
Most reports of SSHL after PDE-5 inhibitor ingestion have come from the U.S. Food and Drug Administration (FDA), which has added SSHL onto the list of potential side effects for all PDE-5 inhibitors.
Study design: Literature review and data gathering from international sources.