Larynx-Preserving Surgery Associated with Improved Survival in Early-Stage Glottic Cancer

What treatment and system factors are associated with survival in early-stage glottic cancer, and how do they compare?

Bottom line
There are a number of treatment and system factors that are significantly associated with early-stage glottis cancer survival when controlling for patient and tumor factors.

Background: Approximately 60% of the estimated 13,560 new cases of larynx cancer in 2015 had their origin in the glottis, typically in an early stage. Current guidelines recommend treatment with either definitive radiotherapy or a partial laryngectomy, and some factors, including facility case volume, patient insurance status, and treatment delay, have been shown to influence survival, but their impact in glottic cancer specifically has not been examined.

Study design: Retrospective study of 5,627 adult patients with early glottic cancer (stage I or II) diagnosed between Jan. 1, 2004, and Dec. 31, 2012.

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