What is the discrepancy rate between frozen section (FS) and permanent section analysis of operative margins from high-risk cutaneous squamous cell carcinomas (SSC) of the head and neck?
Background: SSC is the second most common skin cancer, with approximately 700,000 new U.S. cases diagnosed each year. Several treatment options exist, but Mohs micrographic surgery remains the primary treatment modality. To achieve negative margins, the routine use of FS has also been well established, but for some tumors FS accuracy remains unclear.
Explore this issue:March 2015
Study design: Retrospective review of 41 patients undergoing excision of advanced head and neck SSCs at a single tertiary institution between 2010 and 2013.
Setting: Massachusetts Eye and Ear Infirmary.