Researchers Develop Clinically Relevant Animal Model for Subglottic Injury

Can a clinically aligned, reproducible model for subglottic injury be developed?

Background: Animal models for subglottic stenosis (SGS) have been invaluable in understanding the underlying mechanisms and in developing new prevention strategies. However, most animal models focus on causing a direct mucosal injury to the subglottic region rather than emulating some of the clinical causes such as long-term intubation and/or oversized endotracheal tubes. Additionally, the methods associated with direct injury models can have constraints due to ethical approval and high mortality rates congruent with the large stenosis induced in these models.

Study design: Prospective randomized control pilot study.

Setting: School of Medicine and Medical Science, University College Dublin; National Children’s Research Centre, Our Lady’s Children’s Hospital, Dublin; Diabetes Research Centre, School of Medicine and Medical Science, Conway Institute, University College Dublin; Our Lady’s Children’s Hospital, Dublin, Ireland.

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