Does a neural reflex exist that links the esophagus and the nasal airway, possibly explaining a mechanism for the association between gastroesophageal reflux (GER) disease and chronic rhinosinusitis (CRS)?
Background: Many studies have shown an association between GER and CRS. The leading theory on the pathogenic mechanism is direct reflux of gastric acid into the proximal airway, leading to mucosal injury. This association has been demonstrated in both pediatric and adult populations, using esophageal and nasopharyngeal pH testing.
Study design: Prospective study