Which factors influence the development of a second head and neck cancer? Are there new factors that could be used to identify patients at greatest risk for the development of a second primary malignancy?
Background: Multiple malignancies of the upper aerodigestive tract are commonly encountered. The patient’s susceptibility may be influenced by mutation-induced chromosomal fragility, and gene aberrations such as P53 may play a role.
Explore this issue:August 2015
Study design: Researchers followed a group of 96 consecutive patients who were treated between 1987-1991 with irradiation therapy for squamous cell carcinoma. Eligibility required that the patient had adequate tissue available. All patients had been followed for at least six years. Suspicious new primaries were biopsied. The definition of a second primary required that it be at least 2 cm from the index tumor or at least three years after the index tumor. Tissue was assessed with the bleomycin test for chromosomal fragility and microsatellite analysis.
This is a single-institution, retrospective study of tissue available from previously treated patients. Genetic analysis, as well as polymerase chain reaction (PCR) and single-strand confirmation, polymorphism analysis, and nucleotide sequence analysis were employed.