Is treatment with chemotherapy alone feasible for advanced laryngeal or hypopharyngeal squamous cell carcinoma? Background: A favorable response to induction chemotherapy has been shown to be predictive of response to chemoradiation in patients with advanced laryngeal squamous cell cancer. Because of the adverse long-term sequelae of radiation therapy, including fibrosis and dysphagia, this study sought to […]
Induction Chemo May Be Superior to Chemoradiotherapy Alone in Unresectable Head And Neck Cancer
ORLANDO-Concurrent chemoradiotherapy (CRT) is considered standard treatment for unresectable advanced head and neck cancer. A new study presented at the 2009 meeting of the American Society of Clinical Oncology (ASCO) suggests that induction chemotherapy (IC) delivered before CRT significantly improved time to treatment failure (TTF) compared with standard upfront CRT alone in this setting.