ENTtoday
  • Home
  • COVID-19
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

What Is the Role of Induction Chemotherapy in the Treatment of Locally Advanced Sinonasal Squamous Cell Carcinoma?

by Arash Abiri, BS, Maie A. St. John, MD, PhD, and Edward C. Kuan, MD, MBA • January 18, 2023

  • Tweet
  • Email
Print-Friendly Version

TRIO Best Practice

TRIO Best Practice articles are brief, structured reviews designed to provide the busy clinician with a handy outline and reference for day-to-day clinical decision making. The ENTtoday summary below includes the Background and Best Practice sections of the original article. To view the complete Laryngoscope article free of charge, visit Laryngoscope.

You Might Also Like

No related posts.

Explore This Issue
January 2023

BACKGROUND

Sinonasal neoplasms represent a distinct subset of head and neck malignancies exhibiting a wide spectrum of histopathologies and divergent biological behaviors. Squamous cell carcinoma (SCC) accounts for a majority of these tumors and is traditionally managed surgically. However, close proximity to critical structures, such as the skull base and orbit, can make surgical resection a challenge, especially in the context of locoregionally advanced disease. As a result, sinonasal SCC extending to the orbit has often necessitated radical excision with orbital exenteration to achieve clear surgical margins. Management of the skull base has evolved over time, with minimally invasive techniques providing comparable outcomes to traditional open craniofacial approaches. Over the years, the advent of endoscopic surgery and advancements in multimodal treatment strategies have increasingly enabled treatment protocols to favor organ-preserving management for advanced malignancies (Head Neck. 2019;41:2777–2788). Induction chemotherapy (IC), in particular, has shown promise, with reports suggesting its ability to improve morbidity and survival outcomes in select patients with locally advanced disease (Int Forum Allergy Rhinol. 2019;9:212–219). Herein, we review some of the most recent and highest levels of evidence that have investigated IC and its role in managing locoregionally advanced sinonasal SCC.

BEST PRACTICE

Locally advanced sinonasal SCC demonstrates a wide spectrum of disease, and susceptibility to IC remains largely observational, with no reliable pretreatment predictors. Patients may benefit from a trial of IC used in an attempt to downgrade tumor extension into nearby structures and facilitate organ preservation. The potential benefits of IC must be weighed against its associated adverse effects, however, especially in more vulnerable patient populations. Pathological response to IC may prognosticate long-term patient outcomes (“bioselection”), as an effective response to IC appears to portend a lower likelihood of recurrence and higher overall survival and disease-free survival. Therefore, a response-dependent treatment protocol (Figure 1), wherein subsequent definitive therapy is dictated by IC response, may be warranted until further investigations elucidate more optimal treatment strategies.

 

Filed Under: Head and Neck, Head and Neck, Practice Focus, TRIO Best Practices Tagged With: chemotherapyIssue: January 2023

You Might Also Like:

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Rating Laryngopharyngeal Reflux Severity: How Do Two Common Instruments Compare?
    • Vertigo in the Elderly: What Does It Mean?
    • Is Radiofrequency Ablation a Good Alternative to Surgery for Benign Thyroid Nodules? A Look at Benefits, Risks
    • What Happens to Medical Students Who Don’t Match?
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Rating Laryngopharyngeal Reflux Severity: How Do Two Common Instruments Compare?
    • Vertigo in the Elderly: What Does It Mean?
    • Neurogenic Cough Is Often a Diagnosis of Exclusion
    • Complications for When Physicians Change a Maiden Name
    • Smell and Taste Disorder Differences Seen Between Long-Term COVID-19 and non-COVID-19 Patients
    • The Triological Society is Growing in Ethnic and Gender Diversity as Well as Thesis Acceptance
    • No Persistent Postoperative Swallowing Dysfunction Following Pharyngeal Surgery in Patients with Obstructive Sleep Apnea
    • Do the Principles of Adult Learning Maximize Training Efficiency and Efficacy for Pediatric Otolaryngologists?
    • Prolonged Operative Time Associated with Multiple Adverse Outcomes in Endoscopic Sinonasal Surgery

Polls

Do you think that women have made large enough strides in otolaryngology leadership and gender equity?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use
  • Cookie Preferences

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2023 The Triological Society. All Rights Reserved.
ISSN 1559-4939