What is the association between an increasing degree of papilloma dysplasia and the use of cidofovir in the context of the natural progression of dysplasia in recurrent respiratory papillomatosis (RRP)?
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April 2010Background: RRP is a benign disease characterized by recurrent lesions in the airway. The prevalence and degree of dysplasia present in the natural course of RRP is not well established. While adjuvant therapies such as cidofovir have been used to decrease the interval between repeat surgeries, there has been concern regarding carcinogenic transformation following the use of cidofovir.
Study Design: Retrospective chart review of 13 patients with RRP