What is the pathological evolution and natural history of laryngeal dysplasia, and what is the role of serial excisions in dysplasia grade regression in long-term follow-up?
Background: Vocal fold leukoplakia prevalence in the United States is estimated at 10.2 and 2.1 per 100,000 in males and females, respectively. Pathologic correlation is important because leukoplakia exists on a spectrum from benign hyperkeratosis to premalignant dysplasia to invasive squamous cell carcinoma. As such, most surgeons are reluctant to manage newly diagnosed leukoplakia with watchful waiting, preferring instead to biopsy.
Explore this issue:April 2016
Study design: Retrospective case series of 31 patients treated for vocal fold dysplasia between 1994 and 2013.
Setting: Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston.