What is the impact of chronic rhinosinusitis (CRS) on pediatric patients with cystic fibrosis (CF)?
Despite the high frequency of CRS in the pediatric CF patient population, its impact on quality of life is not well understood. Currently there is no validated, disease-specific, quality of life instrument, available to assess the impact of CRS on the pediatric CF patient population.
Explore this issue:July 2017
Background: Individuals with CF have an incidence of CRS approaching 100%, which is often associated with nasal polyposis (6%–48%); however, data from the U.S. Cystic Fibrosis Foundation’s (CFF) CF Patient Registry indicates that only 2%–3% of pediatric patients per year have sinus disease requiring surgery. Other single-center studies have documented that approximately 10%–20% of CF patients require surgical management of their sinus disease. Despite the high prevalence of CRS in the CF population, little is known about the optimal treatment, indications for surgery, and outcomes of treatment for CF CRS, leading to wide variation in practice patterns.
Study design: PubMed and EMBASE literature review.