—Reviewed by Larry Lundy, MD
Molecular Testing May Improve Differentiated Thyroid Cancer Diagnoses
Can molecular testing for gene point mutations and rearrangements be used to diagnose differentiated thyroid cancer more accurately?
Background: Thyroid cancer progresses through a series of genetic and epigenetic changes. Study authors looked for manuscripts featuring BRAF and RAS gene point mutation, RET/PTC chromosomal rearrangements, PAX8/PPARγ chimeric fusion rearrangement and multigene expression (mRNA) tests. BRAF, RET/PTC and PAX8/PPARγ have a high positive predictive value; gene expression microarrays have a high negative predictive value.