Bottom line: The three studies included in this review do not demonstrate evidence for a clinically significant impact of long-term macrolide therapy for treatment of CRS. However, there may be an effect among the subgroup of patients with low serum IgE, though further study is warranted.
Citation: Pynnonen MA, Venkatraman G, Davis GE. Macrolide therapy for chronic rhinosinusitis: a meta-analysis. Otolaryngol Head Neck Surg. 2013;148:366-373.
—Reviewed by Brent Senior, MD