ENTtoday
  • Home
  • COVID-19
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

Glucocorticoids Effective in Laryngology, but Published Consensus Is Lacking

by Amy Eckner • July 1, 2014

  • Tweet
  • Email
Print-Friendly Version

How are glucocorticoids used for laryngeal pathology, and is there a consensus?

You Might Also Like

  • Oral Steroids Effective in Reducing Inflammation from Phonotrauma
  • More Aggressive Identification Attempts May Prevent Overdiagnosis of Laryngopharyngeal Reflux
  • Is Voice Therapy Effective in Managing Vocal Fold Nodules in Children?
  • Behavior Intervention Effective in Most Patients with Vocal Fold Pseudocysts
Explore This Issue
July 2014

Background: Exogenously administered glucocorticoids are used in clinical practice to reduce inflammation, and interventions that modulate inflammation have a powerful therapeutic potential. However, case series that describe glucocorticoid use in a variety of laryngeal disorders are inconsistent and contradictory, and an understanding of the molecular foundations of glucocorticoid action are often not well understood.

Study design: Literature review.

Setting: New York University School of Medicine, New York City.

Synopsis: Glucocorticoids are powerful and complex immunomodulatory drugs that exert their effects through multiple molecular pathways and mechanisms. They inhibit cyclin dependent kinase activity, which eventually block entry into the S phase of the cell cycle, regulating proliferation of both lymphocytes and fibroblasts. The clinical manifestation of these pathway integrations is inflammation suppression. Glucocorticoids modulate each stage of wound healing, influence epithelial permeability, and are a first-line therapy for many diseases in which defective epithelial barrier function is implicated. For asthma treatment, glucocorticoids decrease admission rates, shorten length of stay, and decrease the time to return of normal activities. They are also effective for hypertrophic scars and skin keloids. Many laryngeal disorders result from an abnormal inflammatory response following trauma, autoimmune disorders, or as a primary infectious or inflammatory process. Foundational studies found that glucocorticoids regulate extracellular matrix metabolism within the vocal folds. There is a lack of consensus and a prescription pattern disparity in clinical studies regarding the appropriate use of these drugs. However, they have been recommended without contraindication for laryngeal trauma from extubation and reintubation, Wegener’s granulomatosis are commonly treated with them, and they have been evaluated as an adjunct to medical or surgical management of benign vocal fold lesions.

Bottom line: Glucocorticoids are effective in the treatment of a number of laryngeal pathologies, through both systemic and intralesional administration, although there is no clear published consensus for their use.

Citation: Rafii B, Sridharan S, Taliercio S, et al. Glucocorticoids in laryngology: a review. Laryngoscope. 2014;124;1668-1673.

Filed Under: Laryngology, Laryngology, Literature Reviews, Practice Focus Tagged With: glucocorticoidsIssue: July 2014

You Might Also Like:

  • Oral Steroids Effective in Reducing Inflammation from Phonotrauma
  • More Aggressive Identification Attempts May Prevent Overdiagnosis of Laryngopharyngeal Reflux
  • Is Voice Therapy Effective in Managing Vocal Fold Nodules in Children?
  • Behavior Intervention Effective in Most Patients with Vocal Fold Pseudocysts

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Experts Delve into Treatment Options for Laryngopharyngeal Reflux
    • Vertigo in the Elderly: What Does It Mean?
    • Weaning Patients Off of PPIs
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Vertigo in the Elderly: What Does It Mean?
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • COVID-19 Impacts on Physician Contracts
    • Do Perioperative Systemic Corticosteroids Improve Cochlear Implant Hearing Preservation?
    • Is Betahistine Effective in the Treatment of Ménière’s Disease?
    • What Is the Role of Radiofrequency Ablation for Benign Thyroid Nodules?
    • Is Preoperative Computed Tomography Necessary for Primary Stapes Surgery?

Polls

Do you ever talk about politics with your patients during appointments?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2021 The Triological Society. All Rights Reserved.
ISSN 1559-4939

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.