Are there neural connectivity changes associated with repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal junction in patients with tinnitus?
Background: Tinnitus pathophysiology is not fully understood. Recent research has shifted to the idea that excessive spontaneous activity in the auditory cortex may explain the amount of bother experienced by tinnitus patients. rTMS uses a magnetic field to create an electric current within the brain that depolarizes axons and activates neural networks; repeated application has the potential to induce changes in neural connectivity.
Explore this issue:May 2016
Study design: Randomized, double blind, controlled clinical trial of 30 patients with subjective, nonpulsatile tinnitus for six months’ duration or longer and a score of ≥ 36 on the Tinnitus Handicap Inventory.
Setting: Department of Otolaryngology–Head and Neck Surgery, Washington University in St. Louis School of Medicine, Mo.