Is nimodipine effective for neuroprotection following cranial nerve injury?
Bottom line: Nimodipine significantly increased the odds of vocal fold motion and facial recovery after injury.
Explore this issue:April 2019
Background: Nimodipine is a calcium channel blocker that has been used to treat hypertension and vasospasm. Various otolaryngology studies suggest that nimodipine exerts a neuroprotective effect on injured neurons, but the exact mechanism remains unknown and no large, multi-institutional clinical trials exist to investigate its efficacy for treatment of various cranial nerve injuries.
Study design: Literature review of nine studies ranging in date from January 1, 1987, to October 11, 2017.