Adult OE progenitors that are normally fated and specified to make only neurons (Neurog1+GBCs) or only neurons and duct/gland cells (Ascl1+ GBCs) have the potential to acquire stem-like multipotency, increased proliferation, and a greater degree of self-renewal in response to epithelial damage.
Background: Adult neurogenesis in the OE is often seen as a unidirectional pathway during homeostasis and repair, resulting in the birth and differentiation of neurons and non-neuronal cells when epithelial repair requires them. At the apex are two multipotent stem cell populations: reserve horizontal basal cells (HBCs) and active globose basal cells (GBCs). Following direct epithelial lesion (surgical ablation of the olfactory bulb [OBX] and direct injury from olfactotoxins methyl bromide [MeBr] or methimazole [MTZ]), both stem cell pools contribute to regeneration.
Study design: Pulse-chase analysis using mice models.