COMMENT: In this important study, researchers from Tufts University provide the first evidence that it is possible to regenerate stem cells of nasal tissue in mice, thus enlarging the population of adult stem cells. The adult stem cells regenerated in mice with injured nasal tissue. When those adult stem cells were transplanted into other mice, they were able to regenerate all the different cell types in the olfactory epithelium. The authors conclude: “If we can restore the population of stem cells in the olfactory epithelium by regenerating them or by administering the right drug as a nasal spray, we may be able to prevent deterioration in the sense of smell.”—Subinoy Das, MD
Can Ascl1+ and Neurog1+ neuronal progenitors in the olfactory epithelium (OE) become multipotent after injury, contributing significantly to tissue regeneration?