ENTtoday
  • Home
  • COVID-19
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

Purpura Formation a Poor Clinical Endpoint for Laser Treatment

by Ravindhra G. Elluru, MD, PhD • January 10, 2011

  • Tweet
  • Email
Print-Friendly Version

How effective are subjective clinical endpoints in determining the effectiveness of laser therapy in the treatment of capillary malformations, also commonly referred to as port wine stains (PWS)?

You Might Also Like

  • Treatment Success Poor for Age-Related Vocal Fold Atrophy
  • KTP and CO2 Laser Fiber Stapedotomy Compared
  • Laser Treatment Resolves Glottic Cancer in a Pilot Study
  • Does Exposure to Laser Plume Place the Surgeon at High Risk for Acquiring Clinical HPV Infection?
Explore This Issue
January 2011

Background: PWS arise from ectatic blood vessels in the dermis. Various lasers are used to selectively photocoagulate these aberrant blood vessels. Purpura formation is commonly used to assess the extent of photocoagulation. This paper explores other methods used to assess the extent of photocoagulation during laser therapy.

Study design: Prospective cohort study

Setting: Beckman Laser Institute and Medical Clinic, University of California, Irvine, and the Scripps Clinic Laser and Cosmetic Dermatology Center, San Diego

Synopsis: A clinic-friendly laser speckle imaging (LSI) instrument was developed and used to provide real-time images of blood flow during laser therapy for PWS. Various lasers were used to treat these subjects, including the modified V-beam, V-beam, Cynergy and alexandrite. A total of 22 subjects (13 female, nine male) with facial PWS were enrolled in the study. Speckle image data were collected both before and about 40 minutes after laser therapy.

Results of these studies demonstrated a poor correlation between purpura formation and the extent of photocoagulation. There was a mean perfusion reduction of at least 20 percent in the majority of patients after a single treatment. In a significant number of patients, there was a heterogeneous response of the PWS to laser treatment. A period of about 30 minutes is required after laser treatment for the overall acute effects of therapy to be adequately assessed.

Bottom line: Purpura formation is a poor clinical endpoint to judge the efficacy of photocoagulation during laser treatment of PWS.

Citation: Huang YC, Tran N, Shumaker PR, et al. Blood flow dynamics after laser therapy of port wine stain birthmarks. Lasers Surg Med. 2009;41(8):563-571.

—Reviewed by Ravindhra G. Elluru, MD, PhD

Filed Under: Literature Reviews Tagged With: clinical, clinical endpoints, laser treatment, PWSIssue: January 2011

You Might Also Like:

  • Treatment Success Poor for Age-Related Vocal Fold Atrophy
  • KTP and CO2 Laser Fiber Stapedotomy Compared
  • Laser Treatment Resolves Glottic Cancer in a Pilot Study
  • Does Exposure to Laser Plume Place the Surgeon at High Risk for Acquiring Clinical HPV Infection?

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Experts Delve into Treatment Options for Laryngopharyngeal Reflux
    • Non-Acidic Reflux Explains Lack of Response to H2 Blockers and PPIs
    • Vertigo in the Elderly: What Does It Mean?
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Vertigo in the Elderly: What Does It Mean?
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Why Virtual Grand Rounds May Be Here to Stay
    • Otolaryngologist Leverages His Love of Pinball into Second Business
    • These New Imaging Advances May Help to Protect Parathyroids
    • Is the Training and Cost of a Fellowship Worth It? Here’s What Otolaryngologists Say
    • Which Otologic Procedures Poses the Greatest Risk of Aerosol Generation?

Polls

Have you used 3D-printed materials in your otolaryngology practice?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2021 The Triological Society. All Rights Reserved.
ISSN 1559-4939

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.