Is the use of topical nasal therapies with saline alone and in combination with antibiotics, antifungals or corticosteroids effective in the treatment of chronic rhinosinusitis (CRS)?
Background: There is a shift from using surgical intervention solely as means to establish a patent drainage for CRS to topical therapy to the mucosa to prevent infection and inflammation and facilitate sinonasal mucociliary clearance. However, evidence for topical nasal therapy use both with and without pharmacologic adjuncts is often contradictory.
Explore this issue:October 2013
Study design: Systematic literature search.
Setting: The Medline database (1966 to May 2012), EMBASE database (1980 to May 2012) and the Cochrane Central Register of Controlled Trials.