Adult-Onset Recurrent Respiratory Papillomatosis May Be Associated with Number of Sexual Partners

What risk factors, if any, are strongly associated with adult-onset recurrent respiratory papillomatosis (AO-RRP)?

Background: Recurrent respiratory papillomatosis (RRP), caused by human papillomavirus (HPV) infection, is characterized by exophytic, benign papillary lesions of the upper aerodigestive tract. Although benign and relatively rare, RRP has a wildly variable disease course and can cause significant morbidity in both children and adults; there is no cure. AO-RRP has a limited body of literature regarding HPV transmission mechanisms or pertinent host risk factors.

Study design: Prospective, age- and sex-matched case control; 121 AO-RRP patients across three institutions who were treated within the last five years (accrual between December 2012 and October 2013) filled out a computer-based, 89-item questionnaire.

Setting: New York University School of Medicine, New York City; New York Eye and Ear Infirmary, New York City; Weill Cornell Medical College, New York City.

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