ENTtoday
  • Home
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

Award-Winning Theses Shed New Light on Treatment Modalities, Disease Etiology

by John Austin • July 1, 2006

  • Tweet
  • Email
Print-Friendly Version

Chicago-Consider this: Over the past two decades, data from both the Surveillance, Epidemiology, and End Results (SEER) program and the National Cancer Database indicate that the survival rates for patients with laryngeal cancer have decreased. During this same time period, the use of nonsurgical treatments for these patients has increased. Is there a relationship?

You Might Also Like

No related posts.

Explore This Issue
July 2006

And this: Laryngomalacia is a common, yet still somewhat enigmatic, disease. There are a variety of factors that influence the varying degrees of symptoms and disease severity seen in infants with laryngomalacia. But what do we know about the etiology of the disease and the factors that contribute to the wide spectrum symptoms and outcomes?

While prospective, controlled trials are the gold standard [for evaluating laryngeal cancer treatments], there are clearly some flaws that can be uncovered through review of tumor registries, such as SEER and the National Cancer Database.

Those are just two of the questions addressed in this year’s two Mosher Award-winning theses, which were presented as part of the Triological Society’s program here at the 2006 Combined Otolaryngology Spring Meeting (COSM).

Laryngeal Cancer: Demographics, Patterns of Care, and Survival Rates

The last large study of laryngeal cancer in the United States was published in 1997 and compared management in the early 1980s to management in the early 1990s. Over that same time period, data show that the use of irradiation increased and use of surgery as a single treatment modality decreased. A major impetus for that change arose from Veterans Administration Cancer Study Group findings, first published in 1991, that suggested the treatment of advanced laryngeal cancer with induction chemotherapy followed by radiation allows some patients to preserve their larynx without sacrificing cure rates.

This led some researchers to relate that total laryngectomy was no longer useful in the initial treatment of laryngeal cancer and prompted others to identify that, even if survivals are only equivalent, organ-preservation approaches should be the treatment of choice, said thesis author Henry T. Hoffman, MD, Professor of Otolaryngology-Head and Neck Surgery at the University of Iowa in Iowa City. However, this raises the question as to whether organ preservation approaches provide equivalent survival when offered outside of a controlled study.

While prospective, controlled trials are the gold standard, Dr. Hoffman said, there are clearly some flaws that can be uncovered through review of tumor registries, such as SEER and the National Cancer Database (NCDB).

Mining Tumor Registries

The National Cancer Database accrues 60 percent of its patients from community hospitals, so this is truly a reality check showing what’s going on in the country, Dr. Hoffman said. The SEER data set samples approximately 25 percent of the US and identified statistically significant improvement in survival from the mid 1980s to the mid 1990s for 23 of the 24 cancer sites examined. The single site that showed a decrease across these time periods was the larynx.

Pages: 1 2 3 4 | Single Page

Filed Under: Departments, Laryngology, Medical Education, Practice Focus Tagged With: cancer, COSM, etiology, laryngeal cancer, outcomes, reflux, research, treatmentIssue: July 2006

You Might Also Like:

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Second Victims: The Effects of a Medical Error on Physicians Can Be Devastating
    • Advanced Degrees Can Help Otolaryngologists Better Understand the Business of Medicine
    • How to: A Dynamic Endonasal Columellar Strut Placement
    • Rating Laryngopharyngeal Reflux Severity: How Do Two Common Instruments Compare?
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Rating Laryngopharyngeal Reflux Severity: How Do Two Common Instruments Compare?
    • Vertigo in the Elderly: What Does It Mean?
    • What Happens to Medical Students Who Don’t Match?
    • Complications for When Physicians Change a Maiden Name
    • Qualitative Research Shows How Patients Feel About Quality-of-Life Issues
    • How to: A Dynamic Endonasal Columellar Strut Placement
    • Second Victims: The Effects of a Medical Error on Physicians Can Be Devastating
    • Advanced Degrees Can Help Otolaryngologists Better Understand the Business of Medicine
    • Laser Laryngeal Surgery Is Safe Under THRIVE

Polls

Have you ever been, or have you ever known someone who has been a second victim?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use
  • Cookie Preferences

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2023 The Triological Society. All Rights Reserved.
ISSN 1559-4939