What is the independent effect of human papillomavirus (HPV) on oropharyngeal cancer survival?
Explore this issue:August 2010
Background: HPV has been associated with oropharyngeal cancer risk and appears to underlie the rising incidence of this disease in the U.S. and Europe. HPV-positive oropharyngeal cancers may be associated with a better prognosis than HPV-negative oropharyngeal cancers.
Study design: Retrospective analysis of HPV tumor status and survival of oropharyngeal cancer patients within a phase III randomized trial for stage III/IV squamous cell carcinoma of the head and neck, including 360 patients receiving accelerated fractionation (concomitant boost) radiotherapy with concurrent cisplatin (experimental arm) and 361 patients receiving standard fractionation radiotherapy with concurrent cisplatin (control arm)