Explore this issue:June 2018
What is the current landscape of genetic determinants of HNSCC in low-risk patients?
At present, there is a lack of robust, comprehensive data on genetic drivers of oncogenesis in low-risk patients and a clear need for further research on genetic alterations underlying the rising incidence of HNSCC in low-risk, nontraditional patients.
Background: The past two decades have seen an increased incidence of head and neck squamous cell carcinoma (HNSCC) in a nontraditional, low-risk patient population (i.e., younger than 45 years of age with no history of substance use), owing to a combination of human papillomavirus (HPV) infection and individual genetic variation. Recently, the International Head and Neck Cancer Epidemiology (INHANCE) consortium aimed to compare the role of family history of HNSCC, tobacco, and alcohol as oncologic risk factors among a large cohort of young (≤45 years) and older (≥45 years) patients.| | | Next → | Single Page