Risk of Oral HPV Infections and OSCC Linked to Cumulative Exposure to Oral Sexual Activity

What is the epidemiology of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OSCC)?

Background: Although the twin traditional factors of alcohol and tobacco consumption account for the majority of head and neck squamous cell carcinomas (HNSCC), HPV is now recognized as the etiologic factor driving carcinogenesis for the majority of HNSCCs of the oropharynx in North America and Europe. It is expected that the incidence of HPV-related OSCC in the United States will surpass the incidence of cervical cancer by 2020.

Study design: Systematic review of articles pertaining to the epidemiology of HPV-related OSCC.

Setting: MEDLINE/PubMed from the year 2000 onward.

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