Setting: Tertiary referral center.
Synopsis: Sixty patients with at least six months of unilateral definite Meniere’s disease (AAO-HNS 1995) refractory to medical management were randomized to two treatment groups: low-dose intratympanic gentamicin (ITG) or intratympanic dexamethasone (ITD). Low-dose ITG treatment was defined as 2 mL of 27.6 mg/mL (40 mg/mL buffered). A second treatment was given 20 days later if there were no signs of vestibular dysfunction or significant reduction in calorics. Nineteen patients received one ITG treatment and 13 received the second treatment. Intratympanic administration of dexamethasone was defined as 4 mg/mL once every three days for a total of three injections. Four patients received one retreatment and five patients received two retreatments for uncontrolled vertigo.
Vertigo control was calculated using AAO-HNS 1995 (classes A through F). Two-year follow-up for the ITG group revealed 81 percent complete control (class A) and 12 percent substantial control (class B). In the ITD group, 43 percent obtained complete control (class A) and 18 percent substantial control (class B).| ← Previous | | | Next → | Single Page