Cortisporin Use in Routine Tympanoplasty

Is it safe to use commercially available polymyxin B, neomycin, and hydrocortisone suspension in routine tympanoplasty?

Background: Over the last couple of decades, there have been questions regarding the use of polymyxin B, neomycin, and hydrocortisone suspension (PNH, Cortisporin, Alcon Manufacturing) in tympanoplasty, specifically regarding potential ototoxicity of neomycin. In 2004, an AAO-HNS–sponsored consensus panel published an evidence-based literature review specifically addressing the potential ototoxicity of topical drops in the middle ear. They recommended use of ototoxic drops only if no non-ototoxic drops are available as an alternative and only in infected ears.

Study design: Case series with chart review.

Setting: Private practice.