Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma. Most of the time, it arises in the extremities and retroperitoneum, but it also occurs in the facial sinuses, nasal and oral cavities, nasopharynx, and soft tissues of the neck.
Explore this issue:May 2009
It is relatively uncommon in the head and neck (about 5 percent of the total), but when it does occur, it is usually in soft tissue or, rarely, in the mandible, said Erich Sturgis, MD, MPH, Associate Professor of Head and Neck Surgery and Epidemiology at M. D. Anderson Cancer Center in Houston. There are only about 500 sarcomas of the head and neck each year in the United States.
The disease occurs more commonly in whites than in blacks or Asians, and males develop it about twice as often as females. MFH has a wide age range (10-90 years), but it is most common from age 50 to 70.