ENTtoday
  • Home
  • COVID-19
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

Multispecialty Consortium Introduces Rhinosinusitis Clinical Trial Guidelines.

by Paula Moyer • March 1, 2007

  • Tweet
  • Email
Print-Friendly Version
Bradley F. Marple, MD

You Might Also Like

No related posts.

Explore This Issue
March 2007
Bradley F. Marple, MD

A consortium of 25 allergists and otorhinolaryngologists from five medical specialty societies in the United States has developed a guideline for designing clinical trials in the treatment of chronic rhinosinusitis.

Although the condition affects 30 million people nationwide, there has historically been a lack of consensus regarding its definition, and consensus is still lacking regarding standards of care for it. Therefore, according to the members of the consortium who produced the guidelines, a consensus regarding the design of clinical trials is an important next step to standardizing care.

The new guideline, Rhinosinusitis: Developing Guidance for Clinical Trials, consists of specific recommendations for such trials, and was published in November 2006 in both a supplement of the Journal of Allergy and Clinical Immunology (JACI) and Otolaryngology-Head and Neck Surgery (OTO-HNS).1,2 These are the official publications, respectively, of the American Academy of Allergy, Asthma, and Immunology (AAAAI) and the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS). The other participating societies in the consortium are the American Academy of Otolaryngic Allergy (AAOA), the American College of Allergy, Asthma and Immunology (ACAAI), and the American Rhinologic Society (ARS). This is the group’s second collaboration. The first document was published in December 2004, also concurrently JACI and OTO-HNS.

Acute and Chronic Disease Differentiated

The guideline makes separate recommendations for trials that focus on different subtypes of rhinosinusitis:

  • Acute bacterial rhinosinusitis;
  • Chronic rhinosinusitis, with or without nasal polyps; and
  • Allergic fungal rhinosinusitis.

The goal … has been to provide researchers with the needed methodologies which will promote better clinical studies that can lead to improved patient care, corresponding author, Eli O. Meltzer, MD, said in a statement. He is the Co-Director of the Allergy and Asthma Medical Group and Research Center in San Diego, Calif.

The current publication reviews the FDA’s role in drug trials and offers guidelines for rhinosinusitis clinical trials of various modalities, including antimicrobials, anti-inflammatory agents, and treatments that are designed for symptom relief or the blockage of mediators that promote symptoms. The guidelines also include recommendations of scoring instruments for symptoms, radiographs, endoscopic testing, and quality of life, as well as techniques for quantifying microbiologic factors, assessing inflammatory indices, and statistically measuring outcomes. The guidelines also provide a list of the various components of a rhinosinusitis clinical trial, including the title of the trial, the study design, the objectives, and the safety assessments.

Pages: 1 2 3 4 | Single Page

Filed Under: Articles, Clinical, Features Issue: March 2007

You Might Also Like:

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • Some Studies Predict a Shortage of Otolaryngologists. Do the Numbers Support Them?
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Vertigo in the Elderly: What Does It Mean?
    • Neurogenic Cough Is Often a Diagnosis of Exclusion
    • Complications for When Physicians Change a Maiden Name
    • Vertigo in the Elderly: What Does It Mean?
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • ENTtoday Editor-In-Chief Search
    • Tympanoplasty Tips: Otology Experts Give Advice on the Procedure
    • How Treatment for Obstructive Sleep Apnea (OSA) Is Evolving to Give Patients a Better Night’s Sleep
    • Vestibular Schwannoma Position Relative to Internal Auditory Canal Helps Predict Postoperative Facial Function
    • Vocal Fold Lipoaugmentation Provides Long-Term Voice Improvements for Glottal Insufficiency

Polls

Do you think there will be a shortage of otolaryngologists in the next five to 10 years?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2022 The Triological Society. All Rights Reserved.
ISSN 1559-4939

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.