SAN DIEGO—The use of nonsteroidal anti-inflammatory drugs (NSAIDs) does not lead to increased postoperative bleeding following tonsillectomy, according to two research studies reported during the April 29 American Society of Pediatric Otolaryngology program at the Combined Otolaryngology Spring Meeting.
Explore this issue:July 2007
While tonsillectomy is the most common pediatric surgical procedure and pain the most common preoperative symptom, surgeons have long been concerned about hemorrhage that may be due to the administration of NSAIDs. There are approximately 4500 bleeds following tonsillectomy reported each year in the United States, with reports of one in 40,000 dying from bleeding. The reoperation rate related to the bleeding is 1% to 5.5%.
Cleveland Clinic Study
“However, even though there is significant use of NSAIDs in the public population and the hospital setting, we are not really certain how this affects bleeding,” commented Anita Jeyakumar, MD, a pediatric otolaryngologist at the Cleveland Clinic Foundation, who presented the first paper. “NSAIDs have been shown to reversibly inhibit thromboxane A2 production, potentially leading to inhibition of platelet aggregation, and prolonged bleeding time.”