ENTtoday
  • Home
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Multimedia
    • Video
    • Audio
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

Oral Cavity Cancer Prognosis Has Improved Over Time

by ENT Today • December 11, 2018

  • Tweet
  • Email
Print-Friendly Version

What are the temporal trends demographics, treatment, and prognosis of oral cavity cancer over a 40-year period?

Bottom Line
OCSCC prognosis has improved significantly from the early 1970s to recent years, associated with an increased use of adjuvant therapy and adjuvant chemoradiotherapy in late-stage oral cancer.

You Might Also Like

  • Survival Rates Comparable in Children and Adults with Oral Tongue Squamous Cell Cancer
  • What Additional Treatment Is Indicated for Oral Cavity Cancer with Isolated Perineural Invasion?
  • HPV-Oropharyngeal Cancer Link May Affect Cancer Screening and Prognosis: The link offers potential for improved detection and prevention, but more research is needed
  • New Oral Cavity Cancer Quality Measures Included in Maintenance of Certification (MOC) for Otolaryngologists
Explore This Issue
December 2018

Background: The general therapeutic approach to oral cavity squamous cell carcinoma (OCSCC) — surgery followed by adjuvant radiation in cases with high-risk pathologic features or high-stage disease — has not changed. One exception has been the adoption of adjuvant concomitant chemoradiotherapy for certain high-risk pathologic features, but the extent to which quality of life improvements have truly altered OCSCC prognosis nationally over time is not clear.

Study design: Retrospective database analysis of 16,030 adult patients diagnosed with oral cavity cancer and treated surgically between 1973 and 2014.

Setting: National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) 9 registry; data from the National Cancer Database (NCDB).

Synopsis: Patients were about equally likely to present with early- or late-stage disease. Fewer patients present with low-grade tumors, those with intermediate-grade tumors have increased, and those presenting with high-grade malignancies has stayed consistent. The proportion of patients presenting with a primary on the tongue has increased by half; the proportion presenting with a primary on the floor of the mouth has dropped to almost a third of its initial value. For early-stage disease patients, survival has incrementally improved in each decade since 1973. For late-stage disease patients, survival improved slightly up to 2000, with more dramatic improvements since then. Diagnosis from 2011–2014 had less than half the hazard rate of 1973–1980 diagnosis. Adjuvant radiotherapy use has decreased since 2000 for early-stage OCSCC, but increased for adjuvant chemoradiotherapy use for late-stage OCSCC. Although survival for early- and late-stage disease has improved, the difference in survival between the two has widened. Additionally, death associated with older age as well as higher tumor grade has increased in magnitude over time. Between 1981 and 1990, black race was significantly associated with diminished survival, but this association ceased in 2011. Limitations include uncontrolled variables due to lack of data at source and limited follow-up for patients diagnosed in recent years.

Citation: Cheraghlou S, Schettino A, Zogg CK, Judson BL. Changing prognosis of oral cancer: An analysis of survival and treatment between 1973 and 2014. Laryngoscope. Published online ahead of print September 7, 2018. doi: 10.1002/lary. 27315.

Filed Under: Head and Neck, Literature Reviews Tagged With: mortality rate, oral cavity cancerIssue: December 2018

You Might Also Like:

  • Survival Rates Comparable in Children and Adults with Oral Tongue Squamous Cell Cancer
  • What Additional Treatment Is Indicated for Oral Cavity Cancer with Isolated Perineural Invasion?
  • HPV-Oropharyngeal Cancer Link May Affect Cancer Screening and Prognosis: The link offers potential for improved detection and prevention, but more research is needed
  • New Oral Cavity Cancer Quality Measures Included in Maintenance of Certification (MOC) for Otolaryngologists

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Vertigo in the Elderly: What Does It Mean?
    • Is There a Crisis in the Otolaryngology Match?
    • Experts Delve into Treatment Options for Laryngopharyngeal Reflux
    • New Developments in the Management of Eustachian Tube Dysfunction
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Vertigo in the Elderly: What Does It Mean?
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Post-Tonsillectomy Taste Disorders Rare but Present
    • 10 Novel Ways to Disseminate Scientific Information
    • How to Work with Sales and Marketing Representatives in Your Medical Practice
    • How Medicine Helped Surgeon Prepare for Career as Writer
    • Best Practices for Emergency Surgical Airway
    • Spare Roof Technique Can Improve Patient Quality of Life after Rhinoplasty

Polls

Will registry information and data science improve patient care?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2019 The Triological Society. All Rights Reserved.
ISSN 1559-4939

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.