Perineural Invasion Predictive of Poor Survival Outcomes in Tongue Cancer

Comment: Perineural invasion (PNI) is associated with locoregional recurrence and disease progression in oral cavity squamous cell carcinoma (SCC). Previous retrospective studies have advocated elective neck dissection (END) to reduce locoregional failure and improve survival in patients with early stage oral SCC with PNI. However, this prospective RCT found no benefit of elective neck dissection in PNI-positive (+) patients, highlighting the need for more aggressive neck management in this patient population. —Samuel Selesnick, MD

What is the role of (PNI) in the regional control and survival of patients with tongue SCC?

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