Background: TSCC is the most common oral cancer and is well known for its high propensity to metastasize to cervical lymph nodes. PNI is a distinct pathological feature characterized by the presence of tumor cells within the nerve sheath or perineural space. It remains unclear whether differential prognostic significance of PNI can be observed at different subsites and tumor stages of head and neck cancer.
Study design: Prospective randomized single-center trial, held from November 2008 to September 2014, with a total of 221 cT1-2N0 TSCC patients.
Setting: Department of Oral and Maxillofacial—Head and Neck Oncology, Shanghai Ninth People’s Hospital, China.