ENTtoday
  • Home
  • COVID-19
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

Pregabalin Shows Promise as Treatment Option for Laryngeal Sensory Neuropathy

by Ed Susman • October 1, 2008

  • Tweet
  • Email
Print-Friendly Version

Current common treatments of laryngeal sensory neuropathy include the use of gabapentin and amitriptyline, but those treatments tend to be limited due to sedation and tolerance to the medication, he said.

You Might Also Like

No related posts.

Explore This Issue
October 2008

Details of Pregabalin Study

In the study, doctors collected data on patient demographics, their chief complaint and precipitating factors, treatment, and response. Patients rated their symptoms on a scale of 0 to 5 before and after treatment, Dr. Sycamore explained. We compared the pre- and post-treatment scores of only their chief complaint-globus sensation, throat discomfort, chronic throat clearing, or chronic cough-for this study. We also tracked adverse side effects, drug tolerance, and the ability to wean off the treatment.

The mean age of the patients was 53 years. All patients had acute onset of globus sensation or cough or throat clearing.

Dr. Sycamore said that in four of the patients, the incident of laryngeal sensory neuropathy followed an upper respiratory infection; in another four patients, symptoms followed surgical intervention and intubation. The severity of the patients’ chief complaint was tracked before and after treatments. Of the 10 patients who responded to pregabalin, the pretreatment complaint score was 4.4. After treatment of at least one month, the mean score was 2.1.

In our study we did not find evidence of drug tolerance with pregabalin, Dr. Sycamore said. Sedation was severe enough in two cases to cause patients to discontinue therapy.

Six patients reported improvement at a dose of 150 mg twice a day. Two of these patients required increased their dosing from an initial dose of 75 mg twice a day. The rest of the patients who responded reported improvement on either 75 mg twice a day or 75 mg three times a day. Eight patients continued to take pregabalin for symptom management throughout the 15-month duration of the study, he said.

Implications

Our results indicate that pregabalin is highly effective in treatment of laryngeal sensory neuropathy, improving the chief complaint of globus discomfort, cough, or throat clearing, Dr. Sycamore said. Effective symptom control can be obtained with 75 mg twice a day; however, at least 20 percent of patients required 150 mg twice a day.

Among patients who can tolerate pregabalin, treatment of neuropathy has been shown to be effective for at least 15 months, said Suzan Streichenwein, MD, a private practice psychiatrist in West Palm Beach, FL. Several of these antiepileptic drugs appear to have effectiveness in treatment of various other neuropathies as well.

Pages: 1 2 3 | Single Page

Filed Under: Laryngology, Practice Focus Tagged With: diagnosis, laryngeal sensory neuropathy, laryngology, medication, pregabalin, research, treatmentIssue: October 2008

You Might Also Like:

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Vertigo in the Elderly: What Does It Mean?
    • Neurogenic Cough Is Often a Diagnosis of Exclusion
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Complications for When Physicians Change a Maiden Name
    • Vertigo in the Elderly: What Does It Mean?
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • Otolaryngologists Elected to AMA Board of Trustees
    • FDA Approves First Treatment for Eosinophilic Esophagitis
    • Clinical Best Practices: Otolaryngologists Tackle Questions
    • Otolaryngologist Shares Experience with Image Manipulation in Research and How to Prevent It
    • Methodology to Study Care Barriers for Head and Neck Cancer Patients in Low- and Middle-Income Countries Yields Insights

Polls

Do you think most image manipulation in studies is done accidentally or on purpose?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2022 The Triological Society. All Rights Reserved.
ISSN 1559-4939