ENTtoday
  • Home
  • COVID-19
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

Recurrent Respiratory Papillomatosis: Researchers Advancing Toward Prevention

by John Austin • September 1, 2006

  • Tweet
  • Email
Print-Friendly Version

In looking at patients over an almost 20-year period, they found that if there was a maternal history of genital warts, RRP was seen in 1 of 144 births, but with no warts it was only seen in about 1 of 30,000, Dr. Inglis reported. Only a very small percent of maternal patients were producing about 37 percent of juvenile RRP cases.

You Might Also Like

  • Pediatric Recurrent Respiratory Papillomatosis: Fighting the Battle of a Rare But Serious Disease
  • Suspect Adult Respiratory Papillomatosis with Recurrent Hoarseness after Surgery
  • Recurrent Respiratory Papillomatosis: Much Has Been Done, but a Long Road Lies Ahead
  • Prevalence of Dysplasia with Recurrent Respiratory Papillomatosis Is High
Explore This Issue
September 2006

The researchers also reported that longer delivery times resulted in a slightly increased risk of developing the disease; they saw no association with birth order and only a weak association with younger maternal age.

This study certainly raises the question as to whether elective C-section might be effective to protect against juvenile RRP, Dr. Inglis said. In the US, we have a rate of C-section among juvenile RRP patients of about three percent, compared to a national rate of at least ten percent. The Danish study, though, showed no difference in the rates of elective C-section when comparing the two groups. So, I’d have to say that the jury is still out as to whether elective C-section is actually protective.

The clinical course of juvenile RRP is something like a tale of two databases, said Dr. Inglis, referring to data from a US study and a Danish study.

Figure. Electron micrograph of a negatively stained human papilloma virus.

click for large version
Figure. Electron micrograph of a negatively stained human papilloma virus.

The US study is based on the National Registry for Juvenile-Onset Recurrent Respiratory Papilloma, which was done by the CDC and included more than 600 children from 22 tertiary care centers across the country. The clinical course, as defined by the number of surgeries that the patients had over time, was reported with a median follow-up of 3.6 years.

In some respects, the results of the American study paint a pretty bleak picture, in that the children underwent a mean of 5.1 surgeries annually, Dr. Inglis said. Fortunately, there was not a lot of disease-site progression. In about 75 percent of the patients, the disease remained in the presenting site.

The Danish study included 57 children diagnosed with RRP born between 1974 and 1993. Follow-up averaged approximately 14 years after diagnosis.

Their results painted a much brighter picture. The total median number of surgeries-not the annual, but the total-was five surgeries and 14 percent only required one surgery, he said. With both studies, however, we need to remember that the clinical course does not equal the natural history. I think we need to be skeptical of uncontrolled therapeutic studies.

Traditional Therapies

Obviously, the surgical removal of papilloma requires access and the traditional methods are direct laryngoscopy or bronchoscopy with the possible use of flexible endoscopes.

Pages: 1 2 3 4 | Single Page

Filed Under: Departments, Laryngology, Medical Education, Pediatric, Practice Focus Tagged With: cancer, HPV, medication, pediatrics, pharmaceuticals, prevention, respiratory papillomatosis, surgery, treatment, vaccine, virusIssue: September 2006

You Might Also Like:

  • Pediatric Recurrent Respiratory Papillomatosis: Fighting the Battle of a Rare But Serious Disease
  • Suspect Adult Respiratory Papillomatosis with Recurrent Hoarseness after Surgery
  • Recurrent Respiratory Papillomatosis: Much Has Been Done, but a Long Road Lies Ahead
  • Prevalence of Dysplasia with Recurrent Respiratory Papillomatosis Is High

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Experts Delve into Treatment Options for Laryngopharyngeal Reflux
    • Vertigo in the Elderly: What Does It Mean?
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Is Middle Ear Pressure Affected by Continuous Positive Airway Pressure Use?
    • Vertigo in the Elderly: What Does It Mean?
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Why Virtual Grand Rounds May Be Here to Stay
    • Otolaryngologist Leverages His Love of Pinball into Second Business
    • These New Imaging Advances May Help to Protect Parathyroids
    • Is the Training and Cost of a Fellowship Worth It? Here’s What Otolaryngologists Say
    • Which Otologic Procedures Poses the Greatest Risk of Aerosol Generation?

Polls

Have you used 3D-printed materials in your otolaryngology practice?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2021 The Triological Society. All Rights Reserved.
ISSN 1559-4939

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.