Inactivation of the p53 tumor suppressor is a frequent event in the development of tumors, and alterations or mutations in the gene are reported to occur in almost every type of cancer, at rates varying between 10% (in hematopoietic malignancies) and close to 100% (in high-grade serous carcinoma of the ovary).
In the case of keloids, an aberration in these pathways could influence the activity of TP53. But there are lingering questions that need to be explored, Dr. Garcia-Rodriguez said. “What was most important about this research was that the intermediate regulators and master regulators were found to be important in cell proliferation, senescence, apoptosis, and tumor suppression, suggesting a possible association, indirect or direct, with the development of keloids,” she said. “The big question that our group has was if TP53 is inactivated and there’s an aberrant process occurring with this drug, how come the keloid doesn’t actually turn into a cancer? And do these drugs and master regulators have the ability to influence these processes?”
Self-Directed Learning in Otolaryngology Residents’ Preparation for Surgical Cases
In a nationwide survey, researchers from the Medical College of Wisconsin and the University of Pittsburgh Medical Center found that otolaryngology residents tend to rate their preparation for surgical cases as not particularly effective or efficient, with scores below four on a five-point scale for both junior and senior residents.