ENTtoday
  • Home
  • COVID-19
  • Practice Focus
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Departments
    • Issue Archive
    • TRIO Best Practices
      • Allergy
      • Facial Plastic/Reconstructive
      • Head and Neck
      • Laryngology
      • Otology/Neurotology
      • Pediatric
      • Rhinology
      • Sleep Medicine
    • Career Development
    • Case of the Month
    • Everyday Ethics
    • Health Policy
    • Legal Matters
    • Letter From the Editor
    • Medical Education
    • Online Exclusives
    • Practice Management
    • Resident Focus
    • Rx: Wellness
    • Special Reports
    • Tech Talk
    • Viewpoint
    • What’s Your O.R. Playlist?
  • Literature Reviews
    • Allergy
    • Facial Plastic/Reconstructive
    • Head and Neck
    • Laryngology
    • Otology/Neurotology
    • Pediatric
    • Rhinology
    • Sleep Medicine
  • Events
    • Featured Events
    • TRIO Meetings
  • Contact Us
    • About Us
    • Editorial Board
    • Triological Society
    • Advertising Staff
    • Subscribe
  • Advertise
    • Place an Ad
    • Classifieds
    • Rate Card
  • Search

Resistance Training During Chemoradiotherapy Safe for Patients with HNSCC

by Samara E. Kuehne • August 15, 2017

  • Tweet
  • Email
Print-Friendly Version

Is progressive resistance training (PRT) feasible during concomitant chemoradiotherapy (CCRT) in patients with head and neck squamous cell carcinoma (HNSCC)?

Bottom line
PRT in a clinical setting is safe during CCRT for head and neck cancer, and is associated with high patient satisfaction.

You Might Also Like

  • Fanconi Anemia Patients with HNSCC Tolerate Surgery Better than Radiation, Chemotherapy
  • Olfactory Training Creates Gray Matter Changes in Patients with Hyposmia
  • Limited Data Available on Genetic Drivers of HNSCC in Low- Risk Patients
  • PET-CT is Cost-Effective for N2 Disease After Chemoradiotherapy
Explore This Issue
August 2017

Background: Patients with HNSCC undergoing CCRT frequently experience weight loss, especially loss of lean body mass (LBM), and reduced functional performance. Some data indicate that chemotherapy side effects may be ameliorated by exercise. In patients with head and neck cancer, exercise trials studying training intervention during radiotherapy or CCRT are sparse, but have been gaining ground. The trials all differ in type of intervention, intensity, and frequency, as well as outcome measures, but across these studies, changes in muscle strength, mobility, physical activity, fatigue, diet, and quality of life endpoints in favor of the training intervention group are reported.

Resistance training is an efficient way of maintaining or increasing muscle mass, and the authors of this study wanted to test the feasibility of a 12-week PRT program, as well as the entire study logistics with scans, questionnaires, and controls in their own clinic before launching a randomized trial. Difference in LBM was the primary outcome measure.

Study design: Prospective pilot study.

Synopsis: Twelve patients receiving CCRT participated in a 12-week PRT program. The primary endpoint was feasibility measured as attendance to training sessions. Secondary endpoints included changes in functional performance, muscle strength, and body composition measured by dual-energy X-ray absorptiometry (DXA) scans. Furthermore, sarcomeric protein content, pentose phosphate pathway (PPP) activity, and glycolysis were determined in muscle biopsies. Twelve patients with p16-positive oropharyngeal cancer were enrolled. The primary endpoint was met with nine of the 12 patients completing at least 25 of 36 planned training sessions. The mean attendance rate was 77%. Functional performance was maintained during the treatment period and increased during follow-up. Strength was regained after an initial dip during treatment, paralleling responses in LBM and sarcomeric protein content. LBM began to increase immediately after treatment. The PPP was upregulated after the treatment period, while glycolysis remained unchanged.

No adverse events were related to PRT and in questionnaires, patients emphasized the social and psychological benefits of attendance.

Citation: Lonkvist CK, Vinther A, Zerahn B, et al. Progressive resistance training in head and neck cancer patients undergoing concomitant chemoradiotherapy. Laryngoscope Invest Otol. [Published online July 19, 2017]. doi: 10.1002/lio.88.

Filed Under: Head and Neck, Literature Reviews Tagged With: chemoradiotherapy, clinical outcome, head and neck cancer, progressive resistance training, PRT, therapy, treatmentIssue: August 2017

You Might Also Like:

  • Fanconi Anemia Patients with HNSCC Tolerate Surgery Better than Radiation, Chemotherapy
  • Olfactory Training Creates Gray Matter Changes in Patients with Hyposmia
  • Limited Data Available on Genetic Drivers of HNSCC in Low- Risk Patients
  • PET-CT is Cost-Effective for N2 Disease After Chemoradiotherapy

The Triological SocietyENTtoday is a publication of The Triological Society.

The Laryngoscope
Ensure you have all the latest research at your fingertips; Subscribe to The Laryngoscope today!

Laryngoscope Investigative Otolaryngology
Open access journal in otolaryngology – head and neck surgery is currently accepting submissions.

Classifieds

View the classified ads »

TRIO Best Practices

View the TRIO Best Practices »

Top Articles for Residents

  • Do Training Programs Give Otolaryngology Residents the Necessary Tools to Do Productive Research?
  • Why More MDs, Medical Residents Are Choosing to Pursue Additional Academic Degrees
  • What Physicians Need to Know about Investing Before Hiring a Financial Advisor
  • Tips to Help You Regain Your Sense of Self
  • Should USMLE Step 1 Change from Numeric Score to Pass/Fail?
  • Popular this Week
  • Most Popular
  • Most Recent
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Vertigo in the Elderly: What Does It Mean?
    • Experts Delve into Treatment Options for Laryngopharyngeal Reflux
    • Otolaryngologists Have a Major Role to Play in Treating COVID-19 Long-Haulers
    • Weaning Patients Off of PPIs
    • Vertigo in the Elderly: What Does It Mean?
    • New Developments in the Management of Eustachian Tube Dysfunction
    • Some Laryngopharyngeal Reflux Resists PPI Treatment
    • Eustachian Tuboplasty: A Potential New Option for Chronic Tube Dysfunction and Patulous Disease
    • The Dramatic Rise in Tongue Tie and Lip Tie Treatment
    • Podcasts Becoming More Popular Method of Education for Otolaryngologists
    • How to Embrace Optimism in the Midst of the COVID-19 Pandemic
    • Tips on How to Approach Conversations with Patients about the COVID-19 Vaccine
    • Steps You Should Take to Protect Your Voice and Hearing During Telemedicine Sessions
    • Routine Postoperative Adjunct Treatments Unnecessary for Idiopathic Cerebrospinal Fluid Leaks

Polls

Have you spoken with your patients about receiving the COVID-19 vaccine?

View Results

Loading ... Loading ...
  • Polls Archive
  • Home
  • Contact Us
  • Advertise
  • Privacy Policy
  • Terms of Use

Visit: The Triological Society • The Laryngoscope • Laryngoscope Investigative Otolaryngology

Wiley
© 2021 The Triological Society. All Rights Reserved.
ISSN 1559-4939

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.