Are there differing prognostic factors between human papillomavirus (HPV)-positive and HPV-negative oropharyngeal squamous cell carcinoma (OPSCC), and do sex and race play a part?
Women with HPV-positive OPSCC may have improved overall survival compared to men. Sex does not play a prognostic role in HPV-negative OPSCC, and there are no differences in prognosis by race among HPV-positive or HPV-negative patients.
Explore this issue:October 2018
Background: Between 1975 and 2012, OPSCC incidence increased 62.6% in the U.S., while oral cavity squamous cell cancer declined over the same period. This disparity can be attributed to the rise in HPV-positive OPSCC. HPV-positive and HPV-negative OPSCC are now considered distinct entities, but the clinical factors that influence overall survival for each remain unknown.
Study design: Retrospective case series of 239 incident OPSCC patients (134 HPV-positive, 105 HPV-negative) from 1995 to 2012.