Comment: This manuscript out of Stanford evaluates all 865 patients treated for amyloidosis at the institution over 20 years, and identified a cohort of 22 patients with biopsy-proven laryngeal amyloidosis. The researchers compared this cohort with an age- and sex-matched set of amyloidosis patients with negative laryngoscopy, and show much higher rates of systemic amyloidosis involvement than has previously been shown. The article is of interest due to the relatively higher number of patients in this study compared with prior studies. —Jonathan Bock, MD
What are the differences in clinical presentation and outcomes of laryngeal amyloidosis versus systemic amyloidosis?